Volume 2
- Number 2 (2009)
Volume 3
- Number 1 (2010)
- Number 2 (2010)
Volume 4
- Number 1 (2011)
- Number 2 (2011)
Volume 5
- Number 1 (2012)
- Number 2 (2012)
Volume 6
- 2013
Volume 7
Volume 8
- Number 1 (2015)
- Number 2 (2015)

CALL FOR PAPERS YEAR 2017

IMPORTANT DATES:
Submission Due Date: May 12, 2017
Notification to Authors: May 31, 2017
Journal Publication: July 15, 2017 onwards


EDITORIAL BOARD

Journal of Engineering & Technological Advances
Chief Editor:
Dr. Chia Chee Ming
Deputy Chief Editor:
Dr. Leelavathi Rajamanickam
Editors:
Prof. Omar Munir
Dr. Yap Pow Seng
Pn. Salmaliza Salleh
Mr. Chen Woon Choong
Ms. Kate Lam Woon Yee
 
Asia Pacific Journal of Health Sciences Research
Chief Editor:
Dr Neeraj Malhotra
Deputy Chief Editor:
Prof. Dr. Jamaludin Zainol
Editors:
Datuk Dr Khairiyah Abd Muttalib
Prof. Dr Nyan HL
Assoc. Prof. Tey Kim Kuan
Assoc. Prof. Ong Bee Leng
 
Asia Pacific Journal of Business, Humanities & Education
Chief Editor:
Dr. Mahiswaran Selvanathan
Deputy Chief Editor:
Assoc. Prof. Dr. Stanley Yap
Editors:
Assoc. Prof. Dr. Firdaus Low Abdullah
Dr. Mahadevan Supramaniam
Dr. Chong Wei Ying
Dr. Ramachandran Ponnan
 
 
DYNAMICS OF FACTOR X ACTIVATION BY TISSUE FACTOR-FACTOR VIIa IN A PARALLEL-PLATE FLOW CHAMBER
Author : Ji-Jinn Foo, TseMin Tsai
Formats available : Flipbook (English)
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Abstract
A mathematical model is developed to study the dynamics of enzyme reactions in a flow reactor. Reactions take place on the wall and follow the classical Michaelis-Menten kinetics. The model was solved numerically to simulate factor Xa generation by tissue factor-factor VIIa complex at the surface of cultured rat vascular smooth muscle cells under various wall shear rates for which experimental data have been reported (Hall et al., 1998). Five physical parameters govern the dynamics, namely, the wall shear rate, the initial enzyme concentration, and three reaction rate constants. We demonstrated that the model accurately modeled the experimental data of factor Xa production in the effluent at a fixed wall shear rate once the kon and koff reaction rate constants were specified. The remaining physical parameters, in particular, the initial enzyme concentration, can be determined by fitting against the experimental data. In addition, we showed the average steady-state flux of the combined complex concentration can be used to estimate factor Xa flux under steady state conditions only when wall shear rate is less than 100 sec-1.
 
Authors(s) Affiliations
School of Engineering and the Built Environment, SEGi University College, Selangor, Malaysia; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.